منابع مشابه
APC at a glance.
The gene encoding the adenomatous polyposis coli protein (APC) is mutated in most colon cancers. The major role of APC is thought to be as a scaffold for a protein complex that regulates the phosphorylation and thus degradation of β-catenin in the WNT signalling pathway (Huelsken and Behrens, 2002). However, there is increasing evidence that dysregulation of β-catenin is not the only effect of ...
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A protease inhibitor unsticks cells AI-1 is unique among protease inhibitors because it binds to the matrix protein vitronectin (VN). PAI-1 binding blocks VN's binding site for the cell surface receptor uPAR and for integrin family members. Czekay et al. (page 781) now show that PAI-1 is also able to detach cells through a less direct approach. Unlike the direct competition method, PAI-1 also d...
متن کاملHIV-1 protease mutations and protease inhibitor cross-resistance.
The effects of many protease inhibitor (PI)-selected mutations on the susceptibility to individual PIs are unknown. We analyzed in vitro susceptibility test results on 2,725 HIV-1 protease isolates. More than 2,400 isolates had been tested for susceptibility to fosamprenavir, indinavir, nelfinavir, and saquinavir; 2,130 isolates had been tested for susceptibility to lopinavir; 1,644 isolates ha...
متن کاملPlatelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (chymotryptic protease inhibitor).
The serine protease inhibitors diethyl p-nitrophenyl phosphate and phenylmethylsulfonyl fluoride (chemical modifiers of serine residue) and N-acetyl-l-tryptophan ethyl ester (competitive inhibitor of chymotryptic protease) inhibited 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC; platelet-activating factor)-induced platelet aggregation and secretion. The inhibition was dependent on the p...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2009
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.20.6