Physiological Protease Inhibitor −AT, APC

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APC at a glance.

The gene encoding the adenomatous polyposis coli protein (APC) is mutated in most colon cancers. The major role of APC is thought to be as a scaffold for a protein complex that regulates the phosphorylation and thus degradation of β-catenin in the WNT signalling pathway (Huelsken and Behrens, 2002). However, there is increasing evidence that dysregulation of β-catenin is not the only effect of ...

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A protease inhibitor unsticks cells

A protease inhibitor unsticks cells AI-1 is unique among protease inhibitors because it binds to the matrix protein vitronectin (VN). PAI-1 binding blocks VN's binding site for the cell surface receptor uPAR and for integrin family members. Czekay et al. (page 781) now show that PAI-1 is also able to detach cells through a less direct approach. Unlike the direct competition method, PAI-1 also d...

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HIV-1 protease mutations and protease inhibitor cross-resistance.

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Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (chymotryptic protease inhibitor).

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ژورنال

عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis

سال: 2009

ISSN: 1880-8808,0915-7441

DOI: 10.2491/jjsth.20.6